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4-(Methylsulfonyl)phenylhydrazine hydrochloride → 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Methylsulfonyl)phenylhydrazine hydrochloride | HCID 2735181 | — |
| 反応物 | 1-(6-Fluorobenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione | HCID 23285364 | — |
| 生成物 | 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole | HCID 23285367 | 65% |
反応手順
The procedure of Example 9 was repeated using 1-(6-fluorobenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione and 4-methylsulfonylphenylhydrazine hydrochloride as the starting materials to obtain 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole (yield, 65%). NMR(DMSO-d6) δ: 3.30 (3H, s), 7.23 (1H, t, J=54.1 Hz), 7.38-7.46 (1H, m), 7.56 (1H, s), 7.83-7.88 (2H, m), 7.94-7.99 (1H, m), 8.05-8.13 (3H, m); mp 204-206° C. (ethanol)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136831 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-7d206a4b9ae24742a7ac4427a8182c24 |
| 出典メモ | uspto-grants-2000_10 |