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4-(Methylsulfonyl)phenylhydrazine hydrochloride → 6-methyl-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Methylsulfonyl)phenylhydrazine hydrochloride | HCID 2735181 | — |
| 反応物 | 1-(6-Methylbenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione | HCID 23285442 | — |
| 生成物 | 6-methyl-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole | HCID 23285416 | 84% |
反応手順
The procedure of Example 9 was repeated using 1-(6-methylbenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione and 4-methylsulfonylphenylhydrazine hydrochloride as the starting materials to obtain 6-methyl-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole (yield, 84%). NMR(CDCl3) δ: 2.51 (3H, s), 3.10 (3H, s), 6.80 (1H, t, J=54.8 Hz), 7.19 (1H, s), 7.33 (1H, app d, J=8.3 Hz), 7.68 (1H, bs), 7.71-7.74 (2H, m), 7.81 (1H, d, J=8.6 Hz), 8.01-8.04 (2H, m); mp 183-184° C. (ethanol)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136831 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-8b50cc4c8b004ab780d7e9a7f242e339 |
| 出典メモ | uspto-grants-2000_10 |