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Sodium hydride → Ethyl 3-trifluoromethanesulfonyloxy-2-heptenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1,1,1-Trifluoro-N-phenylmethanesulfonamide | HCID 68012 | — |
| 反応物 | Ethyl 3-oxoheptanoate | HCID 559036 | — |
| 反応物 | Diethylether hexane | HCID 21584099 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Diethylether water | HCID 21584184 | — |
| 生成物 | Ethyl 3-trifluoromethanesulfonyloxy-2-heptenoate | HCID 54561069 | — |
反応手順
Ethyl 3-ketoheptanoate (2.07 g, 12 mmol) was dissolved in dimethylformamide (60 mL) under argon and sodium hydride (357 mg, 14.4 mmol) was added. After 30 minutes at room temperature the solid N-phenyltrifluoro-methanesulfonamide (Tetra. Letters, (1983), 24, 979) (4.97 g, 13.8 mmol) was added. The reaction was stirred for 2 hours, diluted with ether/water and the usual workup gave after chromatography with 5:95 ether/hexane 3.45 g (94%) of ethyl 3-trifluoromethanesulfonyloxy-2-heptenoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418250 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-1eeaf04cd8bc43fdbc3683d9c62006b0 |
| 出典メモ | uspto-grants-1995_05 |