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Cyclopropylamine → HCID 178420900、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 反応物 | 6-Chloropurine | HCID 5359277 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178420900 | HCID 178420900 | 153.1% |
反応手順
A solution of 6-chloropurine (Aldrich Chemical Company, 4.23 g, 27 mmoles) and cyclopropylamine (Aldrich Chemical Company, 12.5 g, 22 mmoles) in MeOH (100 ml) was heated at 50° C. for 48 hours. The solvent was removed, and the crude product was purified on a silica gel column eluting with CHCl3 : 5% MeOH to obtain 5.90 g of a cream solid. This was recrystallized from MeOH to give two crops, 2.69 g and 1.16 g (81.4% total yield); mp. 237-240.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05420115 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-27390c5745b6406283dfff51a10e27a3 |
| 出典メモ | uspto-grants-1995_05 |