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Sodium Hydroxide → 2-(1-Methyl-4-imidazolyl)ethylguanidine sulphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | S-methyl isothiourea hemisulfate | HCID 6604939 | — |
| 反応物 | 1-Methylhistamine dihydrochloride | HCID 11957601 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(1-Methyl-4-imidazolyl)ethylguanidine sulphate | HCID 178481270 | — |
反応手順
An aqueous solution of S-methylthiouronium sulphate (2.1 g) is added to a solution prepared from 1-methyl-4-(2-aminoethyl)imidazole dihydrochloride (3.0 g) and sodium hydroxide (1.21 g) in water. The resultant solution is heated under reflux for 17 hours. The product, isolated in a manner similar to that described in Example 1 is recrystallized from aqueous ethanol yielding pure 2-(1-methyl-4-imidazolyl)ethylguanidine sulphate, m.p. 280°-282° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04088769 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-ab8156ea395f48b1abfaeb368f94d37e |
| 出典メモ | uspto-grants-1978_05 |