関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Norfloxacin | HCID 4539 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-Formyl-4-bromomethylpiperidine | HCID 19812293 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 19812304 | HCID 19812304 | 75% |
反応手順
A mixture of norfloxacin (0.96 g, 3 mmol), 4-bromomethyl-1-formylpiperidine (1.26 g 6.1 mmol) and triethylamine (0.44 g, 0.6 mL, 4.3 mmol) in anhydrous dimethylformamide (15 mL) was heated at 100° C. for 2 hours. The solvent was removed under high vacuum and the residue was dissolved in methanol, filtered and precipitated by the addition of diethyl ether to give the product as a white solid (1.0 g, 75% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05162523 |
|---|
| 出典データセット | uspto-grants-1992_11 |
|---|
| ORD ID | ord-4a20cdc51f8d491aa1351202bd29be4a |
|---|
| 出典メモ | uspto-grants-1992_11 |
|---|
