関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Butyryl chloride | HCID 8855 | — |
| 反応物 | 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile | HCID 79256 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 1-Phenyl-4-cyano-5-(n-propylcarbonylamino)-pyrazole | HCID 18993707 | 50% |
反応手順
6.8 ml (66 mmol) of butyryl chloride were added to a solution of 5.52 g (30 mmol) of 1-phenyl-4-cyano-5-aminopyrazole [known from J. Org. Chem. 21 (1956), 1240] in 70 ml of pyridine. The mixture was heated for 15 hours at 50° C. and then poured into 500 ml of 5% strength by weight aqueous hydrochloric acid. The product was extracted from the aqueous phase with methylene chloride and then isolated in a conventional manner. Yield: 50%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05486618 |
|---|
| 出典データセット | uspto-grants-1996_01 |
|---|
| ORD ID | ord-b4109847d1db4483bc446fb578ac9153 |
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| 出典メモ | uspto-grants-1996_01 |
|---|
