化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,5-Dibromobenzoic acid | HCID 11891 | — |
| 反応物 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 触媒 | Cupric acetate | HCID 8895 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid | HCID 19592213 | 45.1% |
反応手順
A mixture of 2,5-dibromobenzoic acid (25 g, 0.09 mol), DMF (200 ml), 5-amino-1-ethylpyrazole (10 g, 0.09 mol), Cu(OAc)2 (1 g) and K2CO3 (12.3 g, 0.09 mol) was heated at reflux for about 2 days. The reaction mixture was poured into water, acidified with acetic acid and the precipitate which formed was collected by filtration to afford 12.6 g of N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05488055 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-0ac4e72bde0949cb889de7e43a5fb886 |
| 出典メモ | uspto-grants-1996_01 |