化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromo-4,5-dimethoxybenzoic acid | HCID 222963 | — |
| 反応物 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 触媒 | Cupric acetate | HCID 8895 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid | HCID 21217688 | 97.6% |
反応手順
A mixture of 5-amino-1-ethylpyrazole (5.0 g, 45 mmol), 2-bromo-4,5-dimethoxybenzoic acid (11.76 g, 45 mmol), K2CO3 (6.21 g, 45 mmol), Cu(OAc)2 (0.8 g, 400 mmol) and DMF (125 ml) was refluxed overnight. The reaction mixture was cooled, poured into water and acidified with acetic acid. The resulting solid was collected by filtration and dried to afford 12.8 g (97%) of N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05488055 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-01dd962ca2fc4c3ea128f9d346a5bb17 |
| 出典メモ | uspto-grants-1996_01 |