化工社化工社 化学情報印刷レポート · 研究参考用
7-Methylisatin → 3-(Benzyloxyimino)-7-methylindolin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Methylisatin | HCID 14313 | — |
| 反応物 | Benzyloxyamine hydrochloride | HCID 102312 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(Benzyloxyimino)-7-methylindolin-2-one | HCID 136144742 | 68% |
反応手順
To a suspension of 4.91 g of 7-methylisatin in 100 ml of ethanol was added a solution of 5.59 g of O-benzylhydroxylamine hydrochloride and 3.29 g of sodium acetate in 40 ml of water at room temperature. The mixture was stirred at room temperature for 3 hours and concentrated. The concentrate was diluted with chloroform and washed with water. The organic layer was dried over anhydrous sodium sulfate and concentrated. Recrystallization of the crude product from benzene yielded 5.40 g (68%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06031111 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-c88441acf57d43f08a95f1b957719fe0 |
| 出典メモ | uspto-grants-2000_02 |