化工社化工社 化学情報印刷レポート · 研究参考用
Water → [3,4-Bis(methoxymethoxy)]phenacyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| 生成物 | [3,4-Bis(methoxymethoxy)]phenacyl chloride | HCID 18367805 | 78% |
反応手順
4-(Chloroacetyl)catechol (4.1 g, 22 mmol), chloromethylmethylether (3.7 ml, 44 mmol) and triethylamine (12 ml) in tetrahydrofuran (50 ml) were stirred together for 1 h, the mixture poured into water (80 ml) and extracted with diethyl ether (80 ml×2). The organic extract was washed consecutively with 2N aqueous sodium hydroxide (50 ml×2) and water (50 ml), dried (MgSO4), and solvent evaporated to give 4.7 g (78%) of the title compound as a pale brown solid. (The crude product was used in the next step without further purification.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06300363B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-3d5e3b655e424d4fa7c337ff821b9190 |
| 出典メモ | uspto-grants-2001_10 |