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Ethyl orthoformate → Methyl benzo[d]oxazole-7-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Anthranilic acid, 3-hydroxy-, methyl ester | HCID 205248 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | Methyl benzo[d]oxazole-7-carboxylate | HCID 19771047 | 477.6% |
反応手順
A solution of 0.22 g (1.32 mmol) of methyl-2-amino-3-hydroxybenzoate, 0.77 mL (4.6 mmol) of triethylorthoformate and 0.066 g (0.26 mmol) of pyridinium p-toluene sulfonate in 15 mL of xylene was heated at reflux for 18 h. The reaction mixture was concentrated and purified by chromatograph (silica, hexanes:EtOAc, 6:1) to give 0.22 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06303593B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-2cb093ad0c064a02b678eded3a8a4b5c |
| 出典メモ | uspto-grants-2001_10 |