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1-(3-Fluorobenzyl)-1H-indazol-5-amine → N-[1-(3-Fluorobenzyl)-1H-indazol-5-yl]-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]-azepin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Fluorobenzyl)-1H-indazol-5-amine | HCID 7147073 | — |
| 反応物 | tert-Butyl 4-chloro-5,6,7,9-tetrahydro-8H-pyrimido[5',4':4,5]thieno[2,3-c]azepine-8-carboxylate | HCID 58116846 | — |
| 生成物 | N-[1-(3-Fluorobenzyl)-1H-indazol-5-yl]-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]-azepin-4-amine | HCID 58116853 | 63% |
反応手順
The title compound was synthesized in analogy to Example 12A from tert-butyl 4-chloro-5,6,7,9-tetrahydro-8H-pyrimido[5′,4′:4,5]thieno[2,3-c]azepine-8-carboxylate from Example 80A (200 mg, 0.59 mmol) and 1-(3-fluorobenzyl)-1H-indazol-5-amine from Example 8A (149 mg, 0.62 mmol) to yield 213 mg (77% purity, 63% yield), which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524722B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-3dc9163b83654845a25b1927139dafbf |
| 出典メモ | uspto-grants-2013_09 |