3-Chloro-4-(3-fluorobenzyloxy)aniline → tert-Butyl 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-5,8-dihydropyrido[4',3':4,5]furo-[2,3-d]pyrimidine-7(6H)-carboxylate

関与物質

反応手順

tert-Butyl 3-cyano-2-[(1-methoxymethylidene)amino]-4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate from Example 47A (134 mg, 0.44 mmol) and 3-chloro-4-[(3-fluorobenzyl)oxy]aniline from Example 4A (221 mg, 0.88 mmol) were heated in methanol (3.0 mL) in a microwave oven for 1 h at 160° C. The title compound was isolated by preparative HPLC to yield 18 mg (8%).

情報源と証拠