関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | N-Ethylbenzylamine | HCID 84352 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Carbamic chloride, N-ethyl-N-(phenylmethyl)- | HCID 10679448 | — |
反応手順
N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (1.9M in toluene; 2.4 mL, 4.6 mmol) was added over 5 minutes, and the reaction was stirred at room temperature overnight. The mixture was concentrated, and the residue was diluted with diethyl ether (150 mL) and washed twice with H2O. The organic layer was dried and concentrated to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524748B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-ba028587e25a48428392e51037537357 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
