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N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide → [1-(Naphth-2-ylmethyl)piperid-4-yl]urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide | HCID 72002 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | [1-(Naphth-2-ylmethyl)piperid-4-yl]urea | HCID 13145794 | — |
反応手順
1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (prepared acccording to Example 1) is hydrolysed by refluxing in 2N sodium hydroxide to give [1-(naphth-2-ylmethyl)piperid-4-yl]urea(m.p. 183°-5° C.). The product is acylated by reaction with 4-methoxybenzoyl chloride to give the title compound, m.p. of HCL, quarterhydrate=193°-193.5° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722930 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-f835042249204abe88c806390379a6a4 |
| 出典メモ | uspto-grants-1988_02 |