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Methanesulfonyl chloride → N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine | HCID 86649873 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)methanesulfonamide | HCID 87178324 | — |
反応手順
To a solution of EXAMPLE 11A (100 mg, 0.3 mmol) in pyridine (5 mL) was added methanesulfonyl chloride (50 mg, 0.4 mmol). The mixture was stirred at ambient temperature for 5 h and partitioned between ethyl acetate and brine. The organic phase was washed with brine and concentrated. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate to provide the title compound. Yield: 100 mg (82%). MS (DCI/NH3) m/z 430 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383624B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-9a914a045aa04c59866671a9903bff04 |
| 出典メモ | uspto-grants-2013_02 |