化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 3-(Pyridin-3-yl)-5-m-tolylisoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3-Methylphenylacetylene | HCID 136600 | — |
| 反応物 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 生成物 | 3-(Pyridin-3-yl)-5-m-tolylisoxazole | HCID 44546226 | — |
反応手順
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3-methylbenzene (Aldrich, 58 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 2.42 (s, 3H), 7.37 (d, J=7.7 Hz, 1H), 7.48 (t, J=7.6 Hz, 1H), 7.67 (ddd, J=8.0, 4.9, 0.7 Hz, 1 H), 7.74-7.84 (m, 3H), 8.38 (dt, J=7.9, 2.0 Hz, 1H), 8.76 (dd, J=4.7, 1.7 Hz, 1H), 9.15 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 237 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-53a50e2b18cb4c778117fcca8076eb94 |
| 出典メモ | uspto-grants-2013_02 |