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Triphenylphosphine → HCID 68615758、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| 反応物 | 4-Methoxybenzenecarbothioamide | HCID 736827 | — |
| 反応物 | Methyl 4-bromo-3-oxopentanoate | HCID 9815681 | — |
| 反応物 | 2-[2-(4-Methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethanol | HCID 22647510 | — |
| 反応物 | [Rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester | HCID 57792490 | — |
| 生成物 | HCID 68615758 | HCID 68615758 | — |
反応手順
In analogy to the procedure described in example 10 c], [rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester (example 10 b]) was reacted with 2-[2-(4-methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethanol (prepared from [rac]-4-bromo-3-oxo-pentanoic acid methyl ester [PCT Int. Appl. (2001), WO 01/79202] and 4-methoxy-thiobenzamide in analogy to the procedures described in examples 12 a] and 12 b]) in the presence of triphenylphosphine and di-tert-butyl azodicarboxylate to yield [rac]-2-ethoxy-3-(4-{2-[2-(4-methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethoxy}-2-methyl-phenyl)-propionic acid ethyl ester as yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809110B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-c9249ca599fc48ca88cfb16c2ce42693 |
| 出典メモ | uspto-grants-2004_10 |