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HRID 394409作成日：2026年10月24日
Triphenylphosphine → [Rac]-2-ethoxy-3-(4-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic acid methyl ester
https://huagongshe.com/ja/reaction/394409
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| 反応物 | 2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-ethanol | HCID 22647490 | — |
| 反応物 | [Rac]-2-ethoxy-3-(4-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic acid methyl ester | HCID 68617427 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [Rac]-2-ethoxy-3-(4-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic acid methyl ester | HCID 68617201 | — |
反応手順
In analogy to the procedure described in example 1 d], [rac]-2-ethoxy-3-(4-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic acid methyl ester (example 2 c]) was reacted with 2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethanol [PCT Int. Appl. (2001), WO 01/00603 A1] in tetrahydrofuran in the presence of triphenylphosphine and DBAD (di-tert-butyl azodicarboxylate) to yield [rac]-2-ethoxy-3-(4-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic acid methyl ester, which was further saponified in analogy to the procedure described in example 1 e], to yield [rac]-2-ethoxy-3-(4-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic acid as colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06809110B2 |
|---|
| 出典データセット | uspto-grants-2004_10 |
|---|
| ORD ID | ord-e22da669008c42d1881c2763617c7fa1 |
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| 出典メモ | uspto-grants-2004_10 |
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