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Triethylamine → N-{4-[(4-hydroxyphenyl)(methyl)sulfamoyl]phenyl}acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-Acetylsulfanilyl chloride | HCID 8481 | — |
| 反応物 | p-(N-methylamino)phenol sulfate | HCID 10198132 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-{4-[(4-hydroxyphenyl)(methyl)sulfamoyl]phenyl}acetamide | HCID 2998367 | — |
反応手順
4-Methylaminophenol sulfate and equivalent 4-acetamidobenzenesulfonyl chloride and double equivalent triethylamine were reacted in ethanol at room temperature for 4 hours. After the solvent was removed in vacuo, the residue was extracted with diethyl ether. The ether layer was washed successively with 2 N hydrochloric acid, saturated aqueous NaHCO3 solution and water, then dried over anhydrous Na2SO4 The solvent was removed and the residue was recrystallized from ethanol to give N-(4-hydroxyphenyl)-N-methyl-4-acetamidobenzenesulfonamide, mp 202-203° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06605635B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-c49085fcab17466c95941101e1a3525b |
| 出典メモ | uspto-grants-2003_08 |