関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Citrulline | HCID 9750 | — |
| 反応物 | Cyclohexanecarbonyl chloride | HCID 75938 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | N-cyclohexanoyl-(L)-citrulline | HCID 10613142 | 77.5% |
反応手順
L-Citrulline (35.2 g., 0.2 mole) was dissolved in 200 mL of 2 N sodium hydroxide. Cyclohexanoyl chloride (29 mL, 0.2 mole) was added dropwise to the mixture. The reaction mixture was maintained at about 25° C. for 1 hour. The mixture was then acidified to pH 2.6 with aqueous (4:1) hydrochloric acid. The precipitate which formed was separated by decantation. The solids were dissolved in 2 N sodium hydroxide to pH 6.5 and dried by lyophilization to furnish 44.2 g of N-cyclohexanoyl-(L)-citrulline. The product was a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06610329B2 |
|---|
| 出典データセット | uspto-grants-2003_08 |
|---|
| ORD ID | ord-de78eb22f496417d8be36aebed0b2ccf |
|---|
| 出典メモ | uspto-grants-2003_08 |
|---|
