化工社化工社 化学情報印刷レポート · 研究参考用
Cortisol → Hydrocortisone (4-chloro)butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cortisol | HCID 5754 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Chlorobutyryl chloride | HCID 78370 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Hydrocortisone (4-chloro)butanoate | HCID 86595714 | 53% |
反応手順
4 portions of 4-chlorobutanoylchloride (0.32 ml×4) and triethylamine (0.3 g×4) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5, and stirred for 3 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure. The crude residue was ground with hexane and CH2Cl2 to give a white solid with a 53% yield by weight, which had a melting point (m.p.) of 155° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06610676B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-01127625807d4126ba9a0a5612202df9 |
| 出典メモ | uspto-grants-2003_08 |