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Pyrimidine-2-carboxylic acid → 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N'2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrimidine-2-carboxylic acid | HCID 12626245 | — |
| 反応物 | 1-(1H-benzimidazol-2-ylsulfonyl)-N'-hydroxypiperidine-2-carboximidamide | HCID 59085911 | — |
| 生成物 | 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N'2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide | HCID 72511979 | — |
反応手順
The title compound was prepared by a similar method to Preparation 20 from (Z)-1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N′2-hydroxy-2-piperidinecarboximidamide [see Preparation 19] and pyrimidine-2-carboxylic acid (see Chem. Ind. (London), 1954, 786) to afford 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N′2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide as a gum. The title compound was used directly in Example 65.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06610707B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-b78570b2820e42c6a35112e4006ce9ad |
| 出典メモ | uspto-grants-2003_08 |