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N-tert-Butoxycarbonyl-L-tryptophan → (2S)-6-[[(2S)-2-(tert-butoxycarbonylamino)-3-(3H-indol-3-yl)propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-tert-Butoxycarbonyl-L-tryptophan | HCID 83169 | — |
| 反応物 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine | HCID 23552860 | — |
| 生成物 | (2S)-6-[[(2S)-2-(tert-butoxycarbonylamino)-3-(3H-indol-3-yl)propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508607 | — |
反応手順
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using commercially available Nα-tert-butoxycarbonyl-L-tryptophan (90 mg, 0.3 mmol). The final product was triturated with ether to yield 157 mg (81%) of the desired material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06610689B2 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-53e9c980c0024542816feb3242d2b44f |
| 出典メモ | uspto-grants-2003_08 |