関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | 1-Methylhistamine | HCID 3614 | — |
| 反応物 | HCID 56624011 | HCID 56624011 | — |
| 溶媒 | Diisopropylethylamine | HCID 81531 | — |
| 生成物 | HCID 70020694 | HCID 70020694 | — |
反応手順
A mixture of Intermediate 23 (0.075 g, 0.135 mmol), and 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.085 g, 0.677 mmol) in diisopropylethylamine (0.04 ml) and DMSO (0.04 ml), in a sealed vial (e.g. Reacti-vial™) was heated at 85° C. for 40 h. A further portion of 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.085 g, 0.677 mmol) was added after the first 20 h. Purification by Autoprep. HPLC afforded the title compound after freeze drying as a cream solid (0.037 g). LC/MS system B Rt=2.71 mins, m/z=651 MH+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06610665B1 |
|---|
| 出典データセット | uspto-grants-2003_08 |
|---|
| ORD ID | ord-6a2cee94268749dc8854975ee901a27a |
|---|
| 出典メモ | uspto-grants-2003_08 |
|---|
