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Benzaldehyde → Ethyl 2-benzylideneaminobutyrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Ethyl 2-Aminobutyrate Hydrochloride | HCID 12844023 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 2-benzylideneaminobutyrate | HCID 10331026 | 88.9% |
反応手順
A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichioromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817652 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-3c5cb32813c44d02b95d64edcf9341ec |
| 出典メモ | uspto-grants-1998_10 |