関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Glyoxal | HCID 7860 | — |
| 反応物 | 3,4-Diaminotoluene | HCID 10332 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 6-Methylquinoxaline | HCID 242567 | 93% |
反応手順
To a solution of 4-methylbenzene-1,2-diamine (50.0 g, 0.41 mol) in isopropanol (300 mL) was added a solution of glyoxal (40% in water, 65.3 g, 0.45 mol) at room temperature. The reaction mixture was heated at 80° C. for 2 hours and evaporated under vacuum to give 6-methylquinoxaline (55 g, 93%), which was used directly in the next step. 1H NMR (300 MHz, CDCl3) δ 8.77 (dd, J=1.5, 7.2 Hz, 2H), 7.99 (d, J=8.7 Hz, 1H), 7.87 (s, 1H), 7.60 (dd, J=1.5, 8.4 Hz, 1H), 2.59 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08741933B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
|---|
| ORD ID | ord-e5c93eac54194310b75b95b9983e6d88 |
|---|
| 出典メモ | uspto-grants-2014_06 |
|---|
