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4-Chloro-3-(trifluoromethyl)benzaldehyde → 4-{8-[4-Chloro-3-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 118642 | — |
| 反応物 | 4-{2-Oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-ylbenzoic acid hydrochloride | HCID 66764696 | — |
| 生成物 | 4-{8-[4-Chloro-3-(trifluoromethyl)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid | HCID 86685275 | — |
反応手順
The title compound was prepared from 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoic acid hydrochloride salt (20 mg, 0.064 mmol; Example 5-1, Step 4) and 4-chloro-3-trifluoromethylbenzaldehyde (14.68 mg, 0.071 mmol), following essentially the same procedure described in Example 7-1. The title compound was obtained as a white solid (17.4 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08742110B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-2e1a610964984156a708fc3ae721feae |
| 出典メモ | uspto-grants-2014_06 |