関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Bromo-1-(quinolin-6-yl)ethan-1-one | HCID 71699692 | — |
| 反応物 | HCID 178484245 | HCID 178484245 | — |
| 生成物 | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 86630275 | 61.4% |
反応手順
A 100 mL RB flask was charged with 2-bromo-1-(quinolin-6-yl)ethanone (0.7011 g, 2.80 mmol), (E)-N′-(6-chloropyridazin-3-yl)-N,N-dimethylformamidine (0.518 g, 2.80 mmol), and DMF (10.0 ml, 129 mmol), equipped with a reflux condenser, then heated at 105° C. for 3 hours. The reaction mixture was concentrated, then triturated with MeOH to yield (6-chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone (0.530 g, 1.72 mmol, 61%) as a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524900B2 |
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| 出典データセット | uspto-grants-2013_09 |
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| ORD ID | ord-8fc8e95f1cf14139b7f08442945ff403 |
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| 出典メモ | uspto-grants-2013_09 |
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