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Water → (6-Phenylimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 86630275 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 生成物 | (6-Phenylimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 67502844 | — |
反応手順
A 48 mL sealed tube was charged with (6-chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone (0.530 g, 1.72 mmol), phenylboronic acid (0.314 g, 2.58 mmol), cesium carbonate (1.68 g, 5.15 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.0701 g, 0.0858 mmol), 1,4-dioxane (6.31 ml, 73.8 mmol), and water (1.11 ml, 61.8 mmol), flushed with argon, sealed, then placed in an 80° C. oil bath for 8 hours. The mixture was concentrated then triturated with water, followed by MeOH/DCM to give (6-phenylimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone as a reddish brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524900B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-b8134f6526e44278b383ec473be44edb |
| 出典メモ | uspto-grants-2013_09 |