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Acetic Acid → N-(2-bromo-4-(trifluoromethyl)benzyl)-4'-chloro-[1,1'-biphenyl]-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 4-Amino-4'-chlorodiphenyl | HCID 8675 | — |
| 反応物 | 2-Bromo-4-(trifluoromethyl)benzaldehyde | HCID 3020373 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-(2-bromo-4-(trifluoromethyl)benzyl)-4'-chloro-[1,1'-biphenyl]-4-amine | HCID 71059841 | — |
反応手順
Solid NaBH(OAc)3 (1.4 g, 6.8 mmol) was added to a DCE solution (10 mL) of 2-bromo-4-(trifluoromethyl)benzaldehyde (860 mg, 3.4 mmol), 4′-chloro-[1,1′-biphenyl]-4-amine (761 mg, 3.7 mmol), and AcOH (0.78 mL, 13.6 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture diluted with EtOAc washed with water and brine, dried (Na2SO4), dry-packed onto silica gel and purified via column chromatography to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748624B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-adcbe94aa6b841e3be59a4fac222ba32 |
| 出典メモ | uspto-grants-2014_06 |