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Acetonitrile → 1-Chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 3-Chloro-5-hydroxybenzotrifluoride | HCID 3852718 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene | HCID 86674286 | — |
反応手順
Neat chloro(methoxy)methane (1.8 mL, 23.8 mmol) was added to a MeCN solution (20 mL) of 3-chloro-5-(trifluoromethyl)phenol (3.6 g, 18.3 mmol) and Cs2CO3 and the resulting mixture was stirred at room temperature. After 5 h the resulting mixture was diluted with diethyl ether, filtered and concentrated. The resulting material was filtered through a short pad of silica gel, followed by concentration to yield 1-chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748624B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-177aa0b162824e86a5fb13a3dd1817a8 |
| 出典メモ | uspto-grants-2014_06 |