関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-((1S)-1-(4-Bromophenyl)ethyl)acetamide | HCID 793484 | — |
反応手順
To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried with MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530460B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-79330a88ee4444a18d3c367b1401b50e |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
