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Ethyl Bromide → 2-Bromo-5-ethoxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Bromide | HCID 6332 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromo-5-hydroxypyridine | HCID 2762865 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Bromo-5-ethoxypyridine | HCID 23436892 | — |
反応手順
2.51 g (22.99 mmol) 1-bromoethane and 1.99 g (14.37 mmol) K2CO3 are added to a mixture of 1.0 g (5.75 mmol) 2-bromo-5-hydroxypyridine in 100 mL ACN. The mixture is stirred at reflux over night. Then the reaction mixture is poured onto water and extracted with TBME. The organic layer is dried with Na2SO4 and the solvent is removed under vacuo. The residue is purified by column chromatography (silica gel, PE/EtOAC 1/1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530460B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-52b68b2543574d2f8bafa4e5182d8539 |
| 出典メモ | uspto-grants-2013_09 |