関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | ((2-(Allyloxy)pent-4-enyloxy)methyl)benzene | HCID 12996273 | — |
| 触媒 | Benzylidenebis(tricyclohexylphosphine)dichlororuthenium | HCID 11967259 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(benzyloxymethyl)-3,4-dihydro-2H-pyran | HCID 4095658 | — |
反応手順
Benzylidene-bis(tricyclohexylphosphine)dichlororuthenium, bis(tricyclohexylphosphine)benzylidine ruthenium(IV) chloride—Grubbs 1 generation catalyst (0.5 g, 0.54 mmol) was added in one portion to a stirred solution of ((2-(allyloxy)pent-4-enyloxy)methyl)benzene (12) (4 g, 17.2 mmol) in toluene (200 mL). The resulting mixture was heated at 50° C. under N2 for 2 hours before isopropanol (18 mL) and NaOH (0.17 g) were added. The mixture was then heated at 120° C. overnight. The solvent was evaporated and the residue was purified over silica gel using Et2O and hexane to give 2-(benzyloxymethyl)-3,4-dihydro-2H-pyran (13).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08754071B2 |
|---|
| 出典データセット | uspto-grants-2014_06 |
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| ORD ID | ord-969ef71986b049a8a14e414e36aec88f |
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| 出典メモ | uspto-grants-2014_06 |
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