関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 生成物 | (2E)-3-(dimethylamino)-1-[3-(trifluoromethyl)phenyl]prop-2-en-1-one | HCID 5398493 | — |
反応手順
1-[5-(Trifluoromethyl)phenyl]ethanone (0.20 mL, 0.0013 mol) and 1,1-dimethoxy-N,N-dimethylmethanamine (0.17 mL, 0.0013 mol) were combined in a sealed tube and heated in a microwave to 120° C. for 15 minutes, the reaction was allowed to cool and was concentrated to remove the residual DMF acetal, to give (2E)-3-(dimethylamino)-1-[3-(trifluoromethyl)phenyl]prop-2-en-1-one, 0.32 gm, as a red oil, LC/MS (M+H)+: 244.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530485B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-6fbc65bb89434ec29e2e71693ea2bdfb |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
