関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Hydroxyindole | HCID 16054 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 5-Ethoxy-1H-indole | HCID 4777667 | 90% |
反応手順
A mixture of commercially available 5-hydroxy-indole (18 g, 13.5 mmol), anhydrous K2CO3 (93.5 g, 5 equiv) and iodoethane (40.5 ml, 3.75 equiv) in acetone (180 mL) is stirred at 50° C. under argon. When TLC (dichloromethane-methanol, 95:5) indicates the disappearance of 5-hydroxy-indole (4 days), the mixture is filtered, the solid is washed with acetone, then the filtrate is concentrated to give 17.67 g (90%) of the title compound, which is sufficiently pure to be used in the next step. M.p. 144-146° C. (from ethanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530493B2 |
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| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-7954df6899c24f36acc08db5c4700c76 |
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| 出典メモ | uspto-grants-2013_09 |
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