N-(4-bromo-2-fluorophenyl)acetamide → N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide

関与物質

反応手順

Prepared according to procedure B from 4′-bromo-2′-fluoroacetanilide and (1,4-dihydro4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. Off white solid ; mp 245-247° C. 1H-NMR (DMSO-d6) δ10.3 (s,1H), 9.79 (s, 1H), 7.95 (t,1H; J=8.4 Hz), 7.56-7.63(m,3H), 7.47(dd,1H J=1.64, 8.47 Hz), 6.95(d,1H; J=8.9 Hz), 2.1(s, 3H), 1.67(s,6H); MS+APCI [M+H]+ m/z 329. Anal. Calc. For C18H17N2 FO3: C, 65.85, H, 5.22, N, 8.53. Found: C,65.46, H,5.24, N,8.12.

情報源と証拠