化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → p-n-Octadecyloxybenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 反応物 | Methyl 4-(octadecyloxy)benzoate | HCID 4189536 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | p-n-Octadecyloxybenzoic acid | HCID 139993 | 71.4% |
反応手順
The ester 35a (405 mg, 1.0 mmol) was dissolved in 15 ml THF and 50 ml methanol was added. Water (approximately 10 ml) was added until the solution remained cloudy with vigorous stirring, at which time lithium hydroxide monohydrate (840 mg, 20.0 mmol) was added. The reaction mixture was refluxed overnight, acidified with concentrated HCl and cooled. The precipitate was filtered, washed with water and air dried to yield 279 mg (71%) of a white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06569504B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-95cbca864e344aa39a980a29ffce107d |
| 出典メモ | uspto-grants-2003_05 |