関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 4-Methoxybenzylamine | HCID 75452 | — |
| 反応物 | 3-Hydroxyphthalic anhydride | HCID 96580 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Hydroxy-2-(4-methoxy-benzyl)-isoindole-1,3-dione | HCID 59263145 | 81.1% |
反応手順
A mixture of 3-hydroxyphthalic anhydride (543 mg, 3.31 mmol), 4-methoxybenzylamine (0.43 mL, 3.31 mmol) and acetic acid (3 mL) was heated at 100° C. for 4 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (760 mg, 81%). 1H NMR (DMSO-d6) 11.03 (1H, s), 7.61 (1H, dd), 7.28 (1H, d), 7.23-7.19 (3H, m), 6.89-6.86 (2H, m), 4.63 (2H, s), 3.71 (3H, s). MS: [M−H+] 282.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530469B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-26a2cbfbb4d34563afa8982f03fdf0ef |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
