関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 4-Ethoxysalicylic acid | HCID 82628 | — |
| 生成物 | Methyl 4-ethoxy-2-hydroxybenzoate | HCID 4389058 | — |
反応手順
Hydrogen chloride was bubbled into a stirred solution of 4-ethoxy-2-hydroxybenzoic acid (10.10 g, 0.554 mol) in methanol (2000 mL) until the solution was saturated. The solution was heated under reflux for 3 days and then cooled to 15° C. This caused the product to crystallize out. The crystals were collected, rinsed with methanol and hexanes, and dried. Methyl 4-ethoxy-2-hydroxybenzoate was obtained as a pale amber solid (49.3 g) melting at 77°-78° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04724039 |
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| 出典データセット | uspto-grants-1988_02 |
|---|
| ORD ID | ord-72f2082343ba44e69fe8adf60a87217c |
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| 出典メモ | uspto-grants-1988_02 |
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