化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Hydroxy-2-nitrobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-Chloro-2-nitrobenzoic acid | HCID 20902 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Hydroxy-2-nitrobenzoic acid | HCID 293291 | 150.2% |
反応手順
A mixture of 3-chloro-2-nitrobenzoic acid (40 g, 0.20 mol) and KOH (160 g, 2.86 mol) in water (200 mL) was heated to reflux for 16 hr. 6N aqueous hydrochloric acid was added to the mixture to pH=3, then extracted with ethyl acetate (500 mL×4). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give 3-hydroxy-2-nitrobenzoic acid (55 g), LC-MS (ESI) m/z 184 [M+1]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088760B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-f5de328daff54048ac75d1f6e3803ac8 |
| 出典メモ | uspto-grants-2012_01 |