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Thionyl Chloride → benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid | HCID 234339 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate | HCID 2776575 | — |
反応手順
To a stirred solution of 1-(benzyloxycarbonyl)piperidine-3-carboxylic acid (1.05 g, 4 mmol) in anhydrous dichloromethane (10 mL), thionyl chloride (0.573 g, 4.81 mmol) was added drop wise at 0° C. After the addition, the solution was stirred at room temperature overnight. Solvent was removed in vacuum to give benzyl-3-(chlorocarbonyl)piperidine-1-carboxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088760B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-a320e3ceef724816a88a4b0fb3ddc041 |
| 出典メモ | uspto-grants-2012_01 |