benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate → Benzyl-3-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)piperidine-1-carboxylate

関与物質

反応手順

Benzyl-3-(chlorocarbonyl)piperidine-1-carboxylate (0.85 g, 3 mmol) and methyl 3-amino-2-hydroxybenzoate (0.6 g, 3.6 mmol) were added in anhydrous dichloromethane (20 mL) and the mixture was stirred at room temperature overnight. The mixture was extracted with dichloromethane (100 mL×4) and the organic phase was dried with anhydrous sodium sulfate and evaporated under reduced pressure. 1.2 g of benzyl-3-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)piperidine-1-carboxylate was obtained, yield: 97%. LC-MS (ESI) m/z: 413 (M+1)+.

情報源と証拠