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Toluene → (S)-1-(3-bromo-2-methyloxyphenyl)heptane-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Borane;tetrahydrofuran | HCID 2723981 | — |
| 反応物 | 1-(3-Bromo-2-methyloxyphenyl)heptane-1-one | HCID 59544892 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (S)-1-(3-bromo-2-methyloxyphenyl)heptane-1-ol | HCID 59544894 | 98.3% |
反応手順
Under room temperature, a 1M borane THF solution (48 mL) was added to an R-CBS 1M toluene solution (120 mL). 1-(3-Bromo-2-methyloxyphenyl)heptane-1-one (7, 13 g) was added, and the mixture was stirred for 1 hour. Methanol was added, a solvent was distilled off, and the residue was purified by chromatography to obtain (S)-1-(3-bromo-2-methyloxyphenyl)heptane-1-ol (8, 12.86 g, yield 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530668B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-22e2e8a8c04640c3b9b9ef71e66d333a |
| 出典メモ | uspto-grants-2013_09 |