関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | 7-Methylquinoline | HCID 11927 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 7-(Bromomethyl)quinoline | HCID 14168508 | 58% |
反応手順
To a solution of 7-methylquinoline (0.10 g, 0.70 mmol) in 5 ml of CCl4 was added NBS (0.14 g, 0.77 mmol) and AIBN (0.025 g, 0.15 mmol). The reaction mixture was heated at 100° C. for 2 h under nitrogen atmosphere. After the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure and the residue was purified by column chromatography on silica (230-400M) using 1% ethyl acetate/hexane eluent to give the desired product (0.090 g, 58%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08088791B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-5a1b327a6db94cff861080e3841cf9ef |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
