化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → HCID 66621889、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(3-Amino-4-cyano-pyrazol-1-ylmethyl)-benzoic acid methyl ester | HCID 66622281 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 66621889 | HCID 66621889 | 92.4% |
反応手順
To a solution of NaOH (343 mg, 8.58 mmol) in a mixture of water (10 ml) and MeOH (20 ml) the ester 95 (732 mg, 2.86 mmol) was added. The reaction mixture was refluxed 2 min and stirred for additional 2 hrs at ambient temperature. MeOH was removed under reduced pressure and remaining aqueous solution was acidified with conc. HCl (pH 3-4) to form a precipitate which was collected by filtration to afford the title compound (96) (640 mg, 92% yield). LRMS: 242.2 (calc.), 241.1 (found).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088805B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-d817d97b262047d2a4e275c19967742a |
| 出典メモ | uspto-grants-2012_01 |