関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Nitrobenzoyl chloride | HCID 11875 | — |
| 反応物 | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| 反応物 | 3-Amino-4-hydroxypyridine | HCID 233392 | — |
| 反応物 | HCID 178513633 | HCID 178513633 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | P-Xylene | HCID 7809 | — |
| 生成物 | HCID 59680188 | HCID 59680188 | 55% |
| 生成物 | HCID 178522382 | HCID 178522382 | — |
反応手順
N-(4-Hydroxy-pyridin-3-yl)-2-nitro-benzamide was prepared using a procedure similar to that described above using 4-hydroxy-3-aminopyridine and 2-nitrobenzoyl chloride. A mixture of -(4-Hydroxy-pyridin-3-yl)-2-nitro-benzamide (2.6 g, 0.01 mol) and P2S5 (4.44 g, 0.02 mol) in pyridine (12.5 mL) and p-xylene (50 mL) was stirred at 140° C. for 18 hrs. The solvent was removed under vacuo and the residue was purified by recrystallization to give 2-(2-nitrophenyl)thiazolo[4,5-c]pyridine as a yellow solid (1.43 g, yield: 55%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08088928B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-dde622f69e674e3abd2aa110c60d2869 |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
