化工社化工社 化学情報印刷レポート · 研究参考用
2-Fluoro-4-nitrophenol → (7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluoro-4-nitrophenol | HCID 9825 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (7-Chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone | HCID 11173165 | — |
| 反応物 | Ethylacetate methanol | HCID 21584119 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | (7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone | HCID 59424552 | 93.8% |
反応手順
A mixture of 21 (2.4 g, 8.89 mmol), K2CO3 (4.97 g, 35.96 mmol) and 2-fluoro-4-nitrophenol (1.55 g, 9.89 mmol) were heated at 150° C. in diphenyl ether (40 mL) for 2 days. The mixture was purified by column chromatography (eluents EtOAc-hexane 5:95, 2:8, then MeOH-EtOAc 2:98, 5:95) to give the title compound 22 as a yellow solid (3.23 g, 93% yield). MS (m/z): 388.2 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08093264B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-d1ad1ee9b6cc4e188c9675a3c363d9cd |
| 出典メモ | uspto-grants-2012_01 |